Beware of Melatonin: New Side Effect You Should Know About

Melatonin has gained popularity as a natural remedy for insomnia, with many individuals turning to this supplement in hopes of achieving better sleep. However, recent studies have raised concerns about the potential long-term effects of melatonin on heart health. Understanding these implications is crucial for anyone considering this sleep aid.
In this article, we will delve deep into melatonin's impact on our bodies, the reasons behind its widespread use, and the potential risks involved. By the end, you will have a clearer picture of whether this supplement is the right choice for you.
Why Are So Many People Taking Melatonin?
Melatonin is a hormone produced naturally by the pineal gland in the brain, playing a pivotal role in regulating sleep-wake cycles, known as circadian rhythms. Its levels fluctuate throughout the day; they rise in response to darkness and diminish with exposure to light. This hormonal rhythm helps signal to our bodies when it's time to sleep.
For various reasons, some individuals find themselves needing extra melatonin in supplement form:
- Shift Work: People working night shifts may struggle to sleep during the day due to disrupted natural melatonin production.
- Chronic Insomnia: Some individuals experience persistent insomnia that may not respond to lifestyle changes.
- Light Pollution: Exposure to artificial light at night can hinder melatonin production, making supplements appealing.
- Jet Lag: Traveling across time zones can disrupt our circadian rhythms, and melatonin can help reset our internal clocks.
Despite its perception as a harmless natural remedy, it's essential to remember that melatonin supplements may not always be necessary. Sometimes, simple adjustments like reducing screen time before bed or dimming lights can improve sleep quality.
Not All Natural is Safe
While natural products are often seen as benign, this isn't always the case. For example, cicuta is a plant that is as natural as lettuce but is highly toxic. Similarly, while melatonin is generally considered safe, emerging research suggests it might not be as innocuous as previously thought.
The recent study presented at the American Heart Association's Scientific Sessions 2025 involved over 130,000 participants from the United States and the United Kingdom. Researchers analyzed health outcomes of individuals who had taken melatonin for at least a year versus those who had not. The findings indicated a concerning trend: those using melatonin had about a 90% increased risk of developing heart failure over the following five years.
Understanding the Limitations of the Study
It's essential to approach these findings with caution. Several limitations were acknowledged by the study authors:
- The study is observational, meaning it identifies correlations but cannot establish causation.
- Data were primarily sourced from electronic health records, which can vary in accuracy. In the UK, melatonin is prescription-only, ensuring comprehensive tracking. In contrast, the US allows over-the-counter access, potentially skewing results.
- While a 90% increased risk sounds alarming, it's crucial to remember that it doesn't mean 90% of users will experience heart issues. The baseline risk for heart failure remains relatively low.
This context highlights the need for further research to clarify the relationship between melatonin use and cardiovascular health.
Melatonin and Sleep: A Deeper Look
Melatonin supplements are often marketed as a solution for sleep disorders. But how effective are they really? Studies show that melatonin can help some people fall asleep faster, particularly in cases of delayed sleep phase syndrome or for those experiencing jet lag. However, its effectiveness can vary widely among individuals.
It's also worth noting that not all sleep issues stem from a lack of melatonin. Factors such as:
- Anxiety and stress
- Depression
- Chronic pain conditions
- Unhealthy sleep habits
can significantly disrupt sleep patterns, indicating that a comprehensive approach to sleep health is necessary.
Potential Side Effects of Melatonin
While melatonin is often viewed as harmless, it can have side effects that users should be aware of:
- Drowsiness: Some individuals may feel groggy after taking melatonin, impacting daytime alertness.
- Hormonal Effects: Long-term use may influence hormonal balance, potentially affecting menstrual cycles and fertility.
- Digestive Issues: Some users report nausea or diarrhea.
- Interaction with Medications: Melatonin can interact with various medications, including blood thinners and immune suppressants.
What Should You Avoid If Taking Melatonin?
If you decide to take melatonin, consider avoiding the following:
- Alcohol: It can interfere with melatonin's effectiveness and exacerbate side effects.
- Caffeine: Consuming caffeine close to bedtime can negate the benefits of melatonin.
- Heavy Meals: Eating large meals before bedtime can disrupt sleep quality.
Duration of Use: How Long Is Too Long?
Another critical question arises: What happens if you use melatonin for an extended period? While short-term use is generally considered safe, the long-term effects are less understood. Some experts recommend limiting melatonin use to two to three weeks unless advised otherwise by a healthcare professional.
Prolonged use might lead to dependency, where individuals feel unable to sleep without the supplement. As a result, it's essential to explore other sleep solutions and consult a doctor if sleep issues persist.
Conclusion: Proceed with Caution
As the research surrounding melatonin continues to evolve, it's crucial to remain informed and cautious. While it may offer benefits for some, the potential risks, particularly concerning heart health, should not be overlooked. Always consult a healthcare provider before starting any new supplement, especially if you have preexisting conditions or are taking other medications.
To further explore the topic, check out this insightful video:
Ultimately, ensuring a good night's sleep may sometimes require more than a pill. Lifestyle changes, such as establishing a sleep routine, reducing light exposure, and managing stress, can play a significant role in achieving restful sleep.




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